It is an abandoned medical facility, much like The Hospital before it, but contains elements of a mental hospital on top of needles, glass, blood, and disease. Compared to The Hospital, which is simply eerie in appearance, The Clinic is completely haunted by ghosts. Manic was likely created here.
The opening cutscene for The Clinic sees Meat Boy pull out a sword as he and Bandage Girl stare into the distance at Dr. Fetus. Meat Boy then clumsily drops his sword.
A new mechanic introduced in this chapter is Meat Boy and co.'s resillience: Certain obstacles can be withstood for roughly a second before death; this is utilized through the returning needles and newly-introduced glass. Other new features and obstacles introduced include fans, Betus, glass blocks, Spoops, and spin switches.